Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B

Table 4 Diseases associated with the no common molecules between BC genes found in DisGeNET and proteins identified as differentially expressed between MCF7Ecadvar and MCF7pcDNA3 cells. Results obtained with the DisGeNET tool

Gene	Diseases
ECI1	Noninfiltrating intraductal carcinoma
PSMA6	Multiple myeloma, osteosarcoma
PMM2	Adenocarcinoma of lung (disorder)
GPD2	Prostatic neoplasms
HSPA9	Liver neoplasms, secondary malignant neoplasms of liver, liver and intrahepatic biliary tract carcinoma, renal cell carcinoma, leukemia, myeloid leukemia, colorectal carcinoma, colon carcinoma, prostate carcinoma, carcinoma of lung, stomach carcinoma, central neuroblastoma, medullary carcinoma of thyroid, adenocarcinoma, carcinogenesis, neoplasm metastasis, recurrent tumor
HNRNPF	Colorectal neoplasms, glioma, colon carcinoma
EML2	Melanoma, pancreatic carcinoma, Lewis lung malignant neoplasm of pancreas, carcinoma, tumor-associated vasculature
GDI2	Squamous cell carcinoma of esophagus
PDIA3	Liver carcinoma, stomach neoplasms, prostate carcinoma, squamous cell carcinoma, leukemia myelocytic acute, ovarian carcinoma, epithelial ovarian carcinoma, secondary malignant neoplasm of lymph node, malignant neoplasm of larynx, melanoma, cervical adenocarcinoma, secondary malignant neoplasm of lung, adenocarcinoma, carcinogenesis
UBA1	Squamous cell carcinoma, neoplasm metastasis

List of the 11 genes from the 50 that coded for the proteins found with different expression levels between MCF7Ecadvar and MCF7pcDNA3 for which no association was found with the 36 DisGeNET terms that included the words “Breast” or “Mammary,” and “Carcinoma,” “Cancer,” “Neoplasms,” or “Tumorigenesis.” The gene symbol and the diseases in which each of them has been reported altered are indicated. The PSMB3 gene was not found in DisGeNET

ISSN: 2049-3002