Stratification of cancer and diabetes based on circulating levels of formate and glucose

Pietzke, Matthias; Arroyo, Salvador Fernandez; Sumpton, David; Mackay, Gillian M.; Martin-Castillo, Begoña; Camps, Jordi; Joven, Jorge; Menendez, Javier A.; Vazquez, Alexei

doi:10.1186/s40170-019-0195-x

Cancer & Metabolism

Table 2 Studies reporting formate measurements in humans and primates

From: Stratification of cancer and diabetes based on circulating levels of formate and glucose

Study/condition	Country	Sample	Assay	Cases	Controls	Formate	Fold change	Significance	Ref
Death vs asymptomatic/methanol poisoning	Czech Republic	Serum	Enzymatic	6	15	↑	8	4.0E−3	[26]
Amyotrophic lateral sclerosis	India	Serum	NMR	30	25	↑	NR	< 0.001	[24]
Parkinson’s disease vs healthy	India	Serum	NMR	17	22	↑	3	< 0.001	[25]
Crohn’s disease	Canada	Serum	NMR	20	40	↑	NR	< 0.05	[23]
Ulcerative colitis	Canada	Serum	NMR	20	40	↑	NR	< 0.05	[23]
Non-Hodgkin’s lymphoma	Poland	Serum	NMR	26	31	↑	1.7	< 0.05	[18]
Chronic lymphocytic leukaemia	Poland	Serum	NMR	21	31	↑	1.5	< 0.05	[18]
Acute myeloid leukaemia	Poland	Serum	NMR	38	31	↑	2.0	< 0.05	[18]
Colorectal cancer vs healthy	China	Other^a	NMR	127	43	↑	NR	1.0E−3	[17]
Colorectal cancer vs healthy	Denmark	Serum	NMR	153	139	↑	1.2	1.5E−5	[13]
Colorectal cancer vs healthy	China	Serum	NMR	28	55	–	NR	> 0.05	[27]
Chronic pancreatitis vs healthy	China	Plasma	NMR	20	20	↑	NR	< 0.05	[28]
Pancreatic cancer vs healthy	China	Plasma	NMR	19	20	–	NR	> 0.05	[28]
Hepatocellular carcinoma	European	Serum	NMR	114	222	–	NR	> 0.05	[29]
Hepatocellular carcinoma	China	Serum	NMR	24	60	–	0.25	> 0.05	[30]
Hepatocellular carcinoma	China	Serum	NMR	43	18	↓	0.07	< 0.05	[16]
Liver cirrhosis	China	Serum	NMR	42	18	↓	0.36	< 0.05	[16]
Hepatocellular carcinoma vs liver cirrhosis	China	Serum	NMR	43	42	↓	0.20	< 0.001	[16]
Lung cancer vs healthy	China	Serum	NMR	39	43	–	0.87	> 0.05	[31]
Lung cancer vs healthy	Portugal	Plasma	NMR	85	78	↓	0.7	3.6E−5	[14]
Lung cancer vs healthy	China	Serum	NMR	27	24	↓	0.5	NA	[15]
Progressive disease vs response/breast cancer	Singapore	Serum	NMR	7	22	↓	NR	< 0.05	[32]
Obesity vs Non/colorectal cancer	Denmark	Serum	NMR	78	21	↓	NR	7.8E−3	[13]
Type 2 diabetes vs healthy	Other^b	Serum	NMR	8	8	↓	0.3	< 0.05	[12]

^aTumour/normal mucosa
^bRhesus monkeys

Back to article page

ISSN: 2049-3002

Contact us

General enquiries: journalsubmissions@springernature.com