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Table 1 Genetic differences between CCRF CEM and MDA MB231 cell lines

From: Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA

Gene expression

Peripheral blood (acute lymphoblastic)

Breast (adenocarcinoma)

CCRF CEM

MDA MB 231

NAMPT

Intermediate

High

NAPRT

–

High

QPRT

High

Very low

NRK

Low

Intermediate

LDH

Intermediate

Intermediate

PTEN*

Mutation

–

KRAS*

Mutation

Mutation

TP53*

–

Mutation

BRAF*

–

Mutation

CDKN2A*

–

Mutation

  1. *Source: ATCC cell lines by gene mutation