Fig. 1

Glutamine metabolism genes are upregulated in PDA. a Glutamine utilization pathway in PDA. Asp aspartate, GSR glutathione-disulfide reductase. b NQO1 and glutamine metabolism enzymes assessed in patient tumor tissue in PDA versus 17 other cancer types (central columns, “other” cancers include solid and hematological malignancies) and PDA versus normal pancreatic tissue (right most column). Data were obtained from Oncomine (www.oncomine.org). c Kaplan–Meier survival curve corrected for multiple comparisons of 45 PDA patients grouped according to high versus low GOT1:GLUD1 expression assessed using the PROGgene webtool (http://watson.compbio.iupui.edu/chirayu/proggene/database/?url=proggene)