Erratum to: The 2014 Beatson international cancer conference: powering the cancer machine
© Kamphorst and Murphy; licensee BioMed Central Ltd. 2014
Received: 16 December 2014
Accepted: 16 December 2014
Published: 23 December 2014
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Anne Brunet (Stanford University) discussed the metabolic regulation of aging using the C. elegans model. She focused on histone methylation as deficiencies in trimethylation of histone 3 at lysine 4 (H3K4me3) were found to increase lifespan. Regulation of H3K27me3 was also involved in lifespan determination. Brunet further discussed the importance of fat metabolism, in particular the different type of fatty acids, in H3K4me3-deficient worms and how this relates to longevity.
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