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Table 1 Correlation of exchange fluxes with proliferation rate and protein synthesis rate

From: The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

 

Flux per cell versus proliferation rate

Flux per cell versus protein synthesis rate

Flux per cell volume versus proliferation rate

PCC

P

PCC

P

PCC

P

 

Protein synthesis

0.09

0.250214

1.00

0.000000

0.55

0.000004

Essential amino acids

Isoleucine

0.05

0.349331

0.96

0.000000

0.48

0.000082

Leucine

0.08

0.281351

0.98

0.000000

0.54

0.000008

Lysine

0.16

0.108393

0.95

0.000000

0.56

0.000003

Methionine

0.20

0.065968

0.92

0.000000

0.65

0.000000

Phenylalanine

0.12

0.184280

0.97

0.000000

0.59

0.000001

Threonine

−0.01

0.466997

0.92

0.000000

0.42

0.000519

Tryptophan

0.01

0.459913

0.83

0.000000

0.37

0.002299

Valine

0.06

0.333105

0.97

0.000000

0.49

0.000068

Non-essential amino acids

Alanine

0.38

0.000912

−0.55

0.000040

0.11

0.200642

Arginine

0.10

0.230809

0.45

0.001921

0.39

0.001534

Asparagine

0.15

0.134489

0.51

0.000448

0.43

0.000407

Aspartate

0.04

0.373865

0.18

0.081690

0.14

0.151826

Glutamine

−0.23

0.032499

0.78

0.000000

0.13

0.156961

Glutamate

0.26

0.018120

−0.59

0.000080

0.14

0.137636

Glycine

0.51

0.000007

−0.12

0.179629

0.47

0.000066

Proline

0.21

0.047898

−0.30

0.014511

0.03

0.398548

Serine

−0.10

0.226831

0.83

0.000000

0.29

0.012954

Tyrosine

0.07

0.282791

0.96

0.000000

0.52

0.000014

Other

Glucose

−0.17

0.092456

0.80

0.000000

0.21

0.058257

Lactate

0.22

0.043187

−0.76

0.000000

−0.13

0.157716

PPPox

0.34

0.004365

0.66

0.000000

1.00

0.000000

PSAT

−0.16

0.104559

0.73

0.000000

0.24

0.033800

PDH

0.48

0.000078

0.29

0.018433

0.72

0.000000

PC

0.02

0.445333

0.52

0.000207

0.35

0.003715

Glutamate →α-KG

0.05

0.358935

0.80

0.000000

0.64

0.000000

ATP synthase

0.00

0.491256

0.94

0.000000

0.52

0.000014

  1. Correlations between the exchange fluxes of amino acids, lactate and glucose and the predicted flux of selected reactions, with either the protein synthesis rate per cell, the proliferation rate, or the proliferation rate after normalizing by cell volume. PCC, Pearson correlation coefficient; P, associated statistical significance; PPPox, oxidative branch of the pentose phosphate pathway; PSAT, phosphoserine transaminase PC, pyruvate carboxylase; α-KG, α-ketoglutarate. Values in bold indicate significance below P <0.05.
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Cancer & Metabolism

ISSN: 2049-3002