Figure 2
From: Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
Metabolic fingerprint of FH-deficient cell lines. (A) PCA and (B) sigmoidal plot of the metabolomic data from growth media of the indicated cell lines. Results were obtained from nine independent cultures. UOK cells present a distinct metabolic signature compared to their FH-proficient counterpart, UOKpFH. (C) Extracellular and (D) intracellular fumarate and argininosuccinate levels in the indicated cell lines. Results were obtained from three independent cultures and represented as average ± SEM. PCA, principal component analysis; SEM, standard error of the mean; UOK, UOK262.