Characteristics |  | Patients without breast cancer (n = 28,983) | Patients with breast cancer (n = 515) | P values †| ||
---|---|---|---|---|---|---|
 | N (%) | mean (SD) | N (%) | mean (SD) | ||
Basic characteristics | Â | Â | Â | Â | Â | Â |
Age continuous (years) | Â | Â | 66.66 (12.30) | Â | 67.36 (10.35) | 0.129 |
Year at baseline | Â | Â | Â | Â | Â | Â |
    < 2008 |  | 9806 (33.83) |  | 271 (52.62) |  | < 0.001 |
    ≥ 2008 |  | 19,177 (66.17) |  | 244 (47.38) |  |  |
BMI categorical (kg/m2) | Â | Â | Â | Â | Â | Â |
    <30 |  | 11,763 (40.59) |  | 214 (41.55) |  | 0.553 |
    ≥ 30 |  | 10,733 (37.03) |  | 208 (40.39) |  |  |
    missing |  | 6487 (22.38) |  | 93 (18.06) |  |  |
BMI continuous (kg/m2) | Â | Â | 30.52 (6.26) | Â | 30.64 (6.04) | 0.668 |
Smoking status | Â | Â | Â | Â | Â | Â |
    no |  | 23,405 (80.75) |  | 409 (79.42) |  | 0.666 |
    yes |  | 5305 (18.30) |  | 98 (19.03) |  |  |
    missing |  | 273 (0.94) |  | 8 (1.55) |  |  |
A history of cardiovascular diseases | Â | Â | Â | Â | Â | Â |
    no |  | 23,596 (81.41) |  | 418 (81.17) |  | 0.931 |
    yes |  | 5387 (18.59) |  | 97 (18.83) |  |  |
A history of hypertension | Â | Â | Â | Â | Â | Â |
    no |  | 16,696 (57.61) |  | 315 (61.17) |  | 0.115 |
    yes |  | 12,287 (42.39) |  | 200 (38.83) |  |  |
Duration of diabetes categorical (years) | Â | Â | Â | Â | Â | Â |
    < 2 |  | 12,614 (43.52) |  | 224 (43.50) |  | 0.003 |
    ≥ 2, <5 |  | 6798 (23.46) |  | 150 (29.13) |  |  |
    ≥ 5 |  | 9571 (33.02) |  | 141 (27.38) |  |  |
Duration of diabetes continuous (years) | Â | Â | 4.29 (5.15) | Â | 3.81 (4.37) | 0.015 |
HbA1c categorical (%)‡ |  |  |  |  |  |  |
    < 7.0 |  | 18,969 (65.45) |  | 364 (70.68) |  | 0.061 |
    ≥ 7.0, < 8.0 |  | 6873 (23.71) |  | 101 (19.61) |  |  |
    ≥ 8.0 |  | 1463 (5.05) |  | 27 (5.24) |  |  |
    missing |  | 1678 (5.79) |  | 23 (4.47) |  |  |
HbA1c continuous (%)‡ |  |  | 6.77 (1.44) |  | 6.64 (0.92) | 0.003 |
LDL-C categorical (mmol/L)‡ |  |  |  |  |  |  |
    < 2.6 |  | 12,760 (44.03) |  | 224 (43.50) |  | 0.861 |
    ≥ 2.6, < 3.6 |  | 9343 (32.24) |  | 155 (30.10) |  |  |
    ≥ 3.6 |  | 5527 (19.07) |  | 96 (18.64) |  |  |
    missing |  | 1353 (4.67) |  | 40 (7.77) |  |  |
LDL-C continuous (mmol/L)‡ |  |  | 2.76 (1.60) |  | 2.77 (0.98) | 0.876 |
eGFR (mL/min/1.73m2)‡ |  |  |  |  |  |  |
    < 60 |  | 6675 (23.03) |  | 128 (24.85) |  | 0.347 |
    ≥ 60, < 90 |  | 14,292 (49.31) |  | 262 (50.87) |  |  |
    ≥ 90 |  | 7466 (25.76) |  | 115 (22.33) |  |  |
    missing |  | 550 (1.90) |  | 10 (1.94) |  |  |
Metformin‡ |  |  |  |  |  |  |
    no |  | 12,767 (44.05) |  | 262 (50.87) |  | 0.002 |
    yes |  | 16,216 (55.95) |  | 253 (49.13) |  |  |
Sulfonylurea‡ |  |  |  |  |  |  |
    no |  | 20,428 (70.48) |  | 359 (69.71) |  | 0.739 |
    yes |  | 8555 (29.52) |  | 156 (30.29) |  |  |
Insulin‡ |  |  |  |  |  |  |
    no |  | 26,053 (89.89) |  | 474 (92.04) |  | 0.126 |
    yes |  | 2930 (10.11) |  | 41 (7.96) |  |  |
Statins‡ |  |  |  |  |  |  |
    no |  | 13,552 (46.76) |  | 249 (48.35) |  | 0.501 |
    yes |  | 15,431 (53.24) |  | 266 (51.65) |  |  |
Tumor Characteristics | Â | Â | Â | Â | Â | Â |
TNM stage | Â | Â | Â | Â | Â | Â |
    0 |  |  |  | 50 (9.71) |  |  |
    1 |  |  |  | 188 (36.50) |  |  |
    2 |  |  |  | 182 (35.34) |  |  |
    3 |  |  |  | 62 (12.04) |  |  |
    4 |  |  |  | 25 (4.85) |  |  |
    unclear |  |  |  | 8 (1.55) |  |  |
ER | Â | Â | Â | Â | Â | Â |
    negative |  |  |  | 60 (11.65) |  |  |
    positive |  |  |  | 382 (74.17) |  |  |
    unclear |  |  |  | 73 (14.17) |  |  |
PR | Â | Â | Â | Â | Â | Â |
    negative |  |  |  | 102 (19.81) |  |  |
    positive |  |  |  | 289 (56.12) |  |  |
    unclear |  |  |  | 124 (24.08) |  |  |
HER2 | Â | Â | Â | Â | Â | Â |
    negative |  |  |  | 373 (72.43) |  |  |
    positive |  |  |  | 48 (9.32) |  |  |
    unclear |  |  |  | 94 (18.25) |  |  |