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Table 5 Effects of FGFR4 deficiency on mitochondrial biogenesis and energy metabolism in breasts and breast tumor

From: Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

Proteins

WT

KO

Tg

KO-Tg

Cpt1b

1

6.92 (0.24)*

0.13 (0.02)

0.72 (0.04)

Mfn2

1

1.92 (0.34)

0.26 (0.03

0.49 (0.03)

NAMPT

1

0.22 (0.01)

7.64 (0.65)

2.33 (0.37)

Slc25a5

1

0.44 (0.16)

3.92 (0.43)

1.67 (0.23)

Slc25a21

1

0.31 (0.05)

0.60 (0.04)

0.09 (0.02)

Slc25a24

1

0.57 (0.07)

4.14 (0.29)

1.91 (0.13)

Ucp1

1

170.5 (1.57)

0.17 (0.02)

8.54 (0.45)

  1. *Data are mean (SD): p <0.05 (n = 4 for each group). FGFR, fibroblast growth factor receptor; KO, FGFR4 knockout mice; Tg, MMTV-TGFα transgenic mice; KO-Tg, FGFR4−/−: MMTV-TGFα bigenic mice.
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Cancer & Metabolism

ISSN: 2049-3002