Proteins | WT | KO | Tg | KO-Tg |
---|---|---|---|---|
1. Adipokines and adipose enzymes: | Â | Â | Â | Â |
Adiponectin | 1 | 1.64 (0.23)* | 0.01 (0.002) | 0.11 (0.02) |
Adipsin | 1 | 3.32 (0.17) | 0.12 (0.03) | 0.43 (0.06) |
Leptin | 1 | 0.55 (0.04) | 0.003 (0.0001) | 0.05 (0.004) |
Lipoprotein lipase | 1 | 0.92 (0.17) | 0.08 (0.02) | 0.25 (0.06) |
Hormone sensitive lipase | 1 | 2.02 (0.31) | 0.11 (0.02) | 0.31 (0.03) |
2. PPAR gamma targets: | Â | Â | Â | Â |
Fabp4 | 1 | 1.62 (0.26) | 0.04 (0.01) | 0.15 (0.03) |
FASN | 1 | 1.01 (0.23) | 0.14 (0.03) | 0.35 (0.04) |
IRS2 | 1 | 0.12 (0.03) | 1.84 (0.35) | 0.27 (0.08) |
Glut4 | 1 | 0.66 (0.12) | 0.05 (0.003) | 0.18 (0.04) |
SREBP1 | 1 | 0.27 (0.06) | 1.97 (0.29) | 0.33 (0.04) |
3. Adipogenesis regulation: | Â | Â | Â | Â |
(1) Pro-adipogenesis | Â | Â | Â | Â |
Cyclin D1 | 1 | 0.46 (0.10) | 6.61 (0.29) | 3.42 (0.18) |
Cdk4 | 1 | 0.43 (0.08) | 5.14 (0.37) | 2.23 (0.19) |
Cebpd | 1 | 0.24 (0.05) | 7.26 (0.48) | 2.46 (0.15) |
E2F1 | 1 | 0.23 (0.03) | 2.16 (0.36) | 0.71 (0.11) |
Jun | 1 | 0.56 (0.08) | 2.93 (0.26) | 1.52 (0.30) |
Sfrp5 | 1 | 0.55 (0.10) | 0.01 (0.002) | 0.04 (0.005) |
Src | 1 | 0.19 (0.03) | 4.72 (0.51) | 2.31 (0.38) |
Wnt5b | 1 | 0.35 (0.06) | 3.01 (0.23) | 1.37 (0.29) |
(2) Anti-adipogenesis | Â | Â | Â | Â |
Cdkn1a (p21) | 1 | 1.65 (0.18) | 2.44 (0.14) | 3.71 (0.26) |
Dlk1 | 1 | 0.31 (0.04) | 1.03 (0.13) | 0.12 (0.03) |
Klf2 | 1 | 0.007 (0.001) | 1.23 (0.16) | 0.004 (0.0005) |
(3) Others | Â | Â | Â | Â |
Ppara | 1 | 7.33 (0.47) | 0.31 (0.05) | 1.36 (0.17) |
Ucp1 | 1 | 177.1 (1.57) | 0.12 (0.02) | 9.94 (1.03) |